WILL PARALLELS TRANSPORTER AGENT WORK WITH WINDOWS 7 KEYGEN
Many pharmaceutical companies are involved in the development of drugs for the treatment of non-communicable metabolic disorders that are of significant economic interest. Despite continuous efforts, a marked number of effective antimicrobials have not been discovered in the last three decades. Microorganisms develop resistance to antimicrobials in various ways and we have comprehensively discussed the underlying mechanisms that are involved in the development of antibiotic resistance in bacteria in our previous report. Misuse and overuse of antimicrobial agents are the prime reasons for the development of resistance by microbes, which pose a serious health concern to mankind. As per the antibiotic resistance threats report (2019) of the Centers for Disease Control and Prevention (CDC, the United States), the annual death rate due to antibiotic-resistant infection is over 35,000 people in the United States alone. The World Health Organization (WHO) has declared that antimicrobial resistance is one of the top 10 global public health threats facing humanity. There is a swift spread of pan-drug-resistant bacteria at an alarming rate. Unfortunately, the phenomenon of antimicrobial resistance is becoming one of the primary health concerns across the globe, in which the pathogens do not respond to existing antimicrobial agents, which complicates the treatment regimen and thereby increases the mortality rate. The period between 1940 to 1965 is considered the golden era of antibiotics as many new antibiotics were introduced to modern medicine which revolutionized the treatment of bacterial infections. Therefore, they have been used as standard antimicrobial drugs against microbial infections. Thousands of small molecules and peptides were isolated from natural sources such as plants, bacteria, fungi, and marine invertebrates, and some have demonstrated significant antimicrobial activity in preclinical settings and clinics. Overall, this article provides an overview of the importance of considering phytogenous compounds in the development of antimicrobial compounds as therapeutic agents against drug-resistant microbes.Īntimicrobial agents are drugs that are used to prevent and treat infections caused by bacteria, fungi, viruses, and parasites. Additionally, we have also elaborated on the synergetic effect of plant-derived compounds with standard antimicrobials against clinically important microbes. We have also emphasized the role of phytochemicals that target deadly viruses such as COVID-19, Ebola, and dengue. The WHO has categorized some drug-resistant bacteria and fungi as critical and high priority based on the need to develope new drugs, and we have considered the plant metabolites that target these bacteria and fungi. In the present article, we have discussed the importance of plant metabolites in the context of their medicinal applications and elaborated on their mechanism of antimicrobial action against human pathogens. Therefore, it is the need of the hour to discover new antimicrobial agents against drug-resistant pathogens. The World Health Organization (WHO) has declared antimicrobial resistance as one of the top 10 global public health threats facing humanity. Unfortunately, the emergence of antimicrobial resistance has significantly reduced the efficacy of existing standard antimicrobials. Plant-derived natural compounds have been implemented in clinics against microbial diseases. Plants have been used for therapeutic purposes against various human ailments for several centuries.
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